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Mission for a Healthy Nation
Gonoshasthaya Pharmaceuticals Limited (GPL) and Gonoshasthaya Antibiotics Limited (GAL) are the assets of the society and hence the nation. These two companies were developed not for the sake of business and making monetary profits only. Most of the profits of these companies are spent for development and expansion of the factory, training and education of the workers. The rest are allocated for dividend, public welfare projects, research for developing science and technology in Bangladesh.
So, the money a customer pays for purchasing products from GPL and GAL ultimately goes for the benefit of the people of Bangladesh which leads to building a better Bangladesh.
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Principles of GPL and GAL |
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Gonoshasthaya Pharmaceuticals Limited (Manufacturer of WHO listed Essential Drugs) |
Gonoshasthaya Pharmaceuticals Limited (GPL) is a Private Limited Company established in 1981, whose 100% share is owned by Gonoshasthaya Kendra (People's Health Centre), a charitable trust.
It is one of the largest pharmaceutical production units in Bangladesh, established with the aim of producing WHO listed essential drugs in branded generic names with assured internationally expected quality and at reasonable price.
GPL set an example of Technology Transfer to the developing countries, discarding the parable that Less Developed Countries are unable to adapt and use technology required for quality drug manufacture to fulfil the basic needs of their people's health care.
| Objectives of GPL |
Ø To produce essential drugs listed by WHO in branded generic name.
Ø To produce quality drugs at an affordable price for majority of the people of Bangladesh.
Ø To prevent unethical use of drugs. Promote Rational Prescription.
Ø To set standards and examples for the National Drug Policy of Bangladesh.
Ø To develop human resources for Research, Technology Transfer and Quality Assurance.
| GPL at a Glance |
Year of Production : 1981
Location of the Factory : Near National Mausoleum at Savar, Dhaka-1344,
Bangladesh.
Manpower : 275
Production Capacity per Annum : Tablet - 420 million
Capsule - 140 million
Dry Syrup - 1.5 million
Ampoules - 3 million
Vials: Liquid - 1.2 million
Vials: Lyophil - 4 milion
Eye/ear drop - 1.5 million
Ointment - 4 million
Liquids - 3.9 million
Sachets - 15 million
IV Fluid - 0.5 million
Plant Area : 13,378 Sq. m.
Production Floor Area : 11,628 Sq. m.
QC Lab Area : 1,750 Sq. m.
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Gonoshasthaya Pharmaceuticals Limited Care for People and Quality |
Tests and checks made from procurement of Raw/Packing materials to the final marketing are as follows:
| Before Production |
| Characteristics Water Content Crystallinity Particle Size Bulk Density pH Values Specific Optical Rotation Clarity of Solution Sulphated Ash Identification - IR Absorption - Optical Rotation - UV Absorption - Specific Reaction Viable Count Assay - Iodemetric Titration - Potentiometric Titration - Spectrophotometric Method - Microbiological Assay - HPLC - GLC - Flame Photometry |
Solubility Acidity Limit Tests Methanol Content Limit Test for Sulphate Pyrogen LAL Test (Limulus Amebocyte Lysate) Sterility Light Absorption TLC Arsenic Chloride Neutralising Capacity Viable Count Alkalinity Melting Point Dissociation Constant Boiling Point Specific Gravity Heavy Metals Refractive Index |
| During Production |
| Water Purification De-Mineralization Distillation Air-conditioning and Humidity Control Dissolution Test Crimping Assay Mottling In-process Checks - Uniformity of Filling, Weight and Volume - Disintegration - Friability - Capping - Sealing - Chipping - Leak Test |
Viable Count Weight Variation Pyrogen Printing Colour Size Neatness Specific Gravity Space for Overprint Batch Number Manufacturing Date Expiry Date Price Special Marking Machine Trial Machine Cleaning Check up Capping Viscosity Dissolution |
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| After Production |
| Number of Packs per Neatness and Cleanliness Batch Number Manufacturing Date |
Expiry Date Special Marking Carton Packing Outer Carton Packing |
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Quality of Medicine: GPL remains within the specification level of British Pharmacopoeia (BP), United States Pharmacopoeia/National Formulary (USP/NF), European Pharmacopoeia (EP) and International Pharmacopoeia (IP). GPL follows the guidelines of Good Manufacturing Practice (GMP), Good Laboratory Practice and Good House Keeping Practice.
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Research, Development and Quality Assurance: This department is manned with qualified and experienced personnel. It is enriched with modern machinery and equipment. It follows upto date methods to keep up the standards of the products and production.
This department continuously works for development of new drug formulations & doses forms and improvement of existing ones.
This department also maintains a garden rich in medicinal plants to carry out basic research on indigenous drugs with the help of modern science.
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Human Resource Development: GPL continuously trains its workers on modern production technology and techniques to achieve higher efficiency. This helps GPL discharge its social commitments and meet the requirement of Good Manufacturing Practice (GMP). Through training, GPL was able to make the village women work as skilled technicians for producing essential drugs.
Machinery, Equipment and Technology: GPL is continuously keeping abreast the new scientific discoveries and technological advancements. Its procurement list includes a good number of modern, in most of the cases, the latest machinery, equipment and technology.
| Production Environment: GPL possesses a modern factory with scientific, architectural design and plant layout to produce high quality medicines. There is a special arrangement to keep the environment |  |
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| unpolluted from highly sensitive materials such as antibiotics, dangerous chemicals and evaporative substances. |
Customers Complaints: Each complaint is properly dealt as per the format prescribed by International Standards Organization (ISO), which is also in accordance with Good Manufacturing Practice and Good Marketing Practice. Complaints are checked and compared with the Retention Samples and Batch History documents of medicines.
Technical Supports extended by GPL: GPL has earned a name for itself in the fields of training and laboratory experiments. It is called upon by the Chemical Engineering Dept. of Bangladesh University of Engineering & Technology (BUET), Pharmacy Dept of Dhaka University, Pharmacy Dept. of Jahangir Nagar University and Atomic Energy Commission to provide laboratory assistance.
GPL has undertaken the production of research sample medicines for U.S. universities where stringent rules are to be followed for quality control and assurance.
| List of GPL Medicines |
Anaesthetic-Local
| G-Lignocaine 2% G-Lignocaine 2% with Adrenaline |
(Lignocaine hydrochloride BP) (Lignocaine HCl BP 2%+) Adrenaline 10 mcg) |
50 ml vial
50 ml vial |
Anaesthetic-General
| G-Ketamine G-Ketamine |
(Ketamine hydrochloride USP) (Thiopentone Sodium BP) |
Inj. 50 mg/ml vial Inj. 500 mg & 1gm vial with water |
Analgesic, Antipyretic
| G-Aspirin G-Diclofenac G-Paracetamol G-Pethidine G-Morphine |
(Acetyl Salicylic acid BP) (Diclofenac Sodium BP) (Paracetamol BP) (Pethidine Hydrochloride BP) (Morphine Sulphate BP) |
Tablet 100 mg ( coated); 300 mg Tablet 50 mg; Inj. 75 mg/3ml amp. Tablet 500 mg; Syrup 120 mg/5ml bott. Inj. 100 mg/2ml amp. Inj. 100 mg/1ml amp. |
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Antacid |
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G-Antacid Tablet |
(Alu. Hydroxide dried gel BP 250 mg + Mag. Trisilicate BP 500 mg) |
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G-Antacid Suspension |
(Alu. Hydroxide gel BP 125 mg + Mag. Trisilicate BP 500 mg/5 ml) |
Anthelmentics |
G-Levamisole ..............(Levamisole Hydrochloride BP) Syrup 40 mg/5 ml bott.
G-Mebendazole ...........(Mebendazole USP) Tablet 100 mg, 500 mg
G-Albendazole ............(Albendazole USP) Tablet 400 mg
Antianaemia |
G-Iron Folic Acid ........(Ferrous Fumerate PB 200mg+Folic Acid BP 350mcg) Tablet
G-Iron ..................... (Ferrous Sulphate BP) Syrup. 200mg/5ml
Antiallergic |
G-Adrenaline . ...........(Adrenaline Acid tartrate BP) Inj. 1mg/1ml
G-Antihistamine .........(Chlorpheniramine Maleate BP) Tablet 4mg; Syrup 2mg/5ml
Anti-Asthmatic |
G-Salbutamol ...........(Salbutamol sulphate BP) Tablet 4 mg; Syrup 2 mg/5 ml;
..............................Respirator solution 0.5%
G-Theophylline .......(Theophylline sodium glycinate BP) Tablet 300mg;Syrup ..............................120mg/5ml
Anti-Bacterial |
G-Cotrimoxazole ........(Sulphamethoxazole BP 400 mg+ Trimethoprim BP 80 mg) Tablet
..............................(Sulphamethoxazole BP 200 mg+ Trimethoprim BP 40 mg/5 ml) ..............................Suspension.
Antibiotic |
G-Ampicillin ..............(Ampicillin Sodium BP) Inj. 500 mg vial
G-Amoxycillin ...........(Amoxycillin Trihydrate BP) Capsule 250 mg,500mg; Dry syrup ..............................125 mg/5ml(Amoxycillin Sodium BP) Inj. 500 mg vial
G-Benzathine Penicillin (Benzathine Penicillin BP) Inj. 0.6 million unit, 1.2 million unit
G-Cloxacillin ..............(Cloxacillin Sodium BP) Capsule 500 mg; Dry syrup 125 mg/5 ml;
...............................Inj. 500 mg vial
G-Cephalexin ............(Cephalexin Monohydrate BP) Capsule 250 mg; Dry syrup 125 ...............................mg/5 ml
G-Cefradine ..............(Cefradine BP) Capsule 500mg, Inj. 500mg
G-Gentamicin ............(Gentamicin Sulphate BP) Eye/ear drop 0.3%
...............................Inj. 80 mg / 2 ml; 40 mg / 2 ml
G-Pefloxacin .............(Pefloxacin Mesylate Dihydrate INN) Tablet 400 mg; Inj. 400 ...............................mg/5 ml amp.
G-Tetracycline ..........(Tetracycline Hydrochloride BP) Capsule 250 mg; 1% Eye oint.; ...............................3% Skin oint.
G-Penicillin-V ............(Phenoxymethyl Penicillin BP) Tablet 250 mg; Dry syrup 125 ...............................mg/5 ml;
G-Chloramphenicol .....(Chloramphenicol BP) Eye/ear drop 0.5%; Eye oint. 1%
G-Ceftriax ................(Ceftriaxone SodiumUSP)Inj. IV 1 gm, 500 mg; 250 mg vial with ...............................water.Inj. IM 1 gm, 500 mg; 250 mg vial with lignocaine 1%
Anti-consultants, Anti-epileptics |
G-Mag Sulph .............(Magnesium Sulphate BP) Inj. 2.47 gm/5 ml amp.
G-Phenobarbitone ......(Phenbarbitone Sodium BP) Inj. 200mg/1 ml, Tablet 30mg
Anti-dote
G-Naloxone ...............(Naloxone Hydrochloride BP) Inj. 800 mcg/2 ml
Antifungal |
G-Miconazole .............(Miconazole nitrate BP) Cream 2% 20 mg/gm
G-Benzosal ................(Benzoic acid BP 6%+Salicylic acid BP 3%) Ointment 6%+3%
G-G-Vin ....................(Grisofulvin BP) Tablet 500mg
G-Fluconazole ............(Fluconazole BP) Capsule 150mg
Anti-malarial |
G-Chloroquine ............(Chloroquine Phosphate BP) Tablet 150 mg; Syrup 50 mg/5 ml.
G-Quinine .................(Quinine Di-hydrochloride BP) Injection 300 mg / 5 ml amp.
Anti-neoplastic (Antihormone) |
G-Tamoxifen ............(Tamoxifen as citrate BP) Tablet 10 mg, 20 mg (as citrate)
Anti-protozoal |
G-Metronidazole .......(Metronidazole BP) Tablet 200 mg, 400 mg; Infusion ................................500mg/100ml (Benzoyl Metronidazole BP) Syrup 200 mg/5ml
Antiseptic |
G-Antiseptic Solution (Chlorhexidine Gluconate BP 0.3%+ Cetrimide BP 3%) 100 ml
Anti-Spasmodic, Anti-Cholinergic |
G-Atropine ...............(Atropine Sulphate BP) Eye Drop 1%; Inj.0.6 mg/ml amp.
G-Hyoscine ..............(Hyoscine Butyl Bromide BP) Tablet 10 mg; Inj. 20 mg/ml amp.
Anti-Tubercular |
G-Rifampicin .............(Rifampicin USP) Capsule 450 mg
Anti-Ulcerant |
G-Cimetidine ...........(Cimetidine BP) Inj. 200 mg/2 ml amp.
G-Ranitidin .............(Ranitidine Hydrochloride USP) Tablet. 150 mg
Beta-blocker |
G-Propranolol .........(Propranolol Hydrochloride BP) Tablet 40 mg
Cardiovascular |
G-Lisinopril ............(Lisinopril Hydrochloride BP) Tablet 5 mgCalcium Supplements
G-Calcium .............(Calcium Lactate BP) Tablet 300 mg
G-Calcium Gluconate(Calcium Gluconate BP) Inj. 10% 5 ml amp., 10% 10 ml amp.
Cholinesterase Inhibitors |
G-Neostigmine ........(Neostigmine Methyl Sulfate BP) Inj. 0.5 mg/1 ml
Dermatological Anti-infective |
G-Silver Sulfadiazine (Silver Sulfadiazine BP) Cream 1% 25gm, 50gm, 100gm, 200gm, 500gm
Diuretic / Anti hypertensive |
G-Frusemide ..........(Frusemide BP) Tablet 40 mg; Inj. 20 mg/2 ml amp.
G-Thiazide - T .......(Hydrochlorothiazide BP + Triamterene BP) Tablet 25 mg+50 mg
Lubricating Gel |
Shathi Lubricating Gel (Gel of synthetic vegetable gum) 50gm tube
Oral Rehydration Salts |
G-ORS Sodium Chloride BP 1.75 gm
Potassium Chloride BP 0.75 gm
Trisodium Citrate Dihydrate BP 1.45 gm
Glucose Anhydrous BP 10 gm ½ Litre Sachet
Prostaglandin and Oxytocic |
G-Ergometrine ..........(Ergometrine Maleate BP) Inj. 2 mg/1 ml amp.
G-Methyl Ergometrine (Methyl Ergometrine Maleate USP) Tablet 0.125 mg
G-Misoprostol ...........(Misoprostol BP) Tablet 200 mcg Steroid
G-Dexamethasone .....(Dexamethasone sodium phosphate BP) Inj. 5 mg/ml amp.
Tranquillizer |
G-Diazepam (Diazepam BP) Tablet 5 mg; Inj. 10mg/2 ml Tropical Preparation
G-B Benzoate Lotion (Benzyl Benzoate BP) 25% w/v emulsion
Vitamins |
G-Vitamin B Complex Thiamine Hydrochloride BP 5 mg
.............................Riboflavine BP 2 mg
.............................Pyridoxine Hydrochloride BP 2 mg
.............................Nicotinamide BP 20 mg Tablet
G-Vitamin B Complex Thiamine Hydrochloride BP 50 mg
.............................Riboflavine BP 4 mg
.............................Pyridoxine Hydrochloride BP10 mg
.............................Dexpanthenol USP 5 mg Injection
G-Vitamin B1 ..........(Thiamine hydrochloride BP) Tablet 100 mg
G-Vitamin B2 ..........(Riboflavine BP) Tablet 5 mg
G-Vitamin B6 ..........(Pyridoxine hydrochloride BP) Tablet 25 mg
G-Vitamin C ...........(Ascorbic acid BP) Tablet 250 mg
Cytotoxic Drugs |
(Manufacturing begins in July 2003)
G-Lomustine 10mg / Capsule BP
G-Cyclophosphamide 100mg / Inj. / Vial BP Dry Vial
G-Cyclophosphamide 50mg / Tablet BP Coated
G-Fluorouracil 250mg Injection USP Liquid Vial
G-Vinblastine 5mg Injection BP Liquid Vial
G-Vinblastine 10mg Injection BP Liquid Vial
G-Azathioprine 50mg Tablet BP Film Coated
G-Azathioprine 50mg Injection BP Dry Vial
G-Dactinomycin 500mg Injection USP Dry Vial
G-Cisplatin 10mg Injection BP Liquid Vial
G-Doxorubicin 10mg Injection USP Dry Vial
G-Vincristine 1mg Injection BP Ampoule
G-Tamoxifen 10mg Tablet BP Tablet
G-Tamoxifen 20mg Tablet BP Tablet
G-Methotrexete 2.5mg Tablet USP Tablet
G-Methotrexete 25mg in 1ml USP 2ml Ampoule & 10ml Vial